Department of Biochemistry, Zurich University

Cryo-EM

Address

Winterthurer 190
CH 8057 Zurich
Switzerland

Phone:
https://www.bioc.uzh.ch/home/
https://www.bioc.uzh.ch/research/research-groups/medalia/

Contacts

Head

Ohad Medalia
Phone:
Email: omedalia@bioc.uzh.ch

Involved in

  • WG2 - Structural analysis of biomolecules involved in mechanobiology

General description research focus

The overall aim of our work is to understand the cellular remodeling of bio-macromolecules and structure-function relations of large protein machines during cellular processes, using three-dimensional (3D) microscopy approaches. Projects range from the development of molecular markers design to direct imaging of individual protein complexes and cytoskeleton organization to the retrieval of structures of large macromolecular complexes in situ, using 3D averaging of sub-tomograms from eukaryotic cells.

Imaging technologies available

  • Electron Microscopy
  • Correlative Light Electron Microscopy (CLEM)
  • Electron tomography

Equipment available

FEI Tecnai G2 12 LaB6 transmission electron microscope

FEI Tecnai G2 Polara transmission electron microscope

Titan Krios transmission electron microscope 

Expertise support provided to users

EM Sample preparation

Cryo-EM and tomography acquisition

Image processing and 3D reconstructions

Research topics directly investigated in research group

Cell adhesion machinery

Nuclear lamins 

The nuclear pore complex

The structure of intermediate filament proteins

Access rules research groups

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