Smiljanic Kosara

Country: Serbia

Participation in Working Groups

  • WG4 - Mechanobiological principles of rare and common diseases

Research Interests

Molecular neurobiology
Brain aging
Brain injury
Cholesterol metabolism
Dietary restriction (different protocols) and supllementation (omega-3 fatty acid)
Animal and cellular models of AD

Technologies offered to other EuroCellNet participants

Immunihistochemistry (parafin and free-floating sections)
RNA analyzis (PCR, real-time PCR)
Protein analyzis (Western Blotting)
Cell culture

Technologies sought from other EuroCellNet participants

Any techniques relating to the analysis of extracellular and intracellular factors that would enable a better understanding of processes of neurodegeneration and related diseases/disorders.


1. Smiljanic K, Pesic V, Mladenovic-Djordjevic A, Pavkovic Z, Brkic M, Ruzdijic S, Kanazir S. Long-term dietary restriction differentially affects the expression of BDNF and its receptors in the cortex and hippocampus of middle-aged and aged male rats Biogerontology 2015; 16 (1):71-83.
2. Mladenovic Djordjevic A, Perovic M, Smiljanic K, Todorovic S, Tesic V, Ruzdijic S, Kanazir S. The effects of dietary restriction and aging on amyloid precursor protein and presenilin-1 mRNA and protein expression in rat brain. Neuroreport 2014; 25(6):398-403.
3. Smiljanic K, Vanmierlo T, Mladenovic Djordjevic A, Perovic M, Ivkovic S, Lütjohann D, Kanazir S. Cholesterol metabolism changes under long-term dietary restrictions while the cholesterol homeostasis remains unaffected in the cortex and hippocampus of aging rats. AGE 2014; Doi: 10.1007/s11357-014-9654-z
4. Smiljanic K, Vanmierlo T, Mladenovic Djordjevic A, Perovic M, Loncarevic-Vasiljkovic N, Tesic V, Rakic Lj, Ruzdijic S, Lutjohann D, Kanazir S. Aging induces tissue-specific changes in cholesterol metabolism in rat brain and liver. Lipids 2013; 48(11):1069-1077.
5. Smiljanić K, Lavrnja I, Mladenović-Đorđević A, Ruždijić S, Peković S, Kanazir S. Brain injury induces cholesterol 24-hydroxylase (Cyp46) expression in glial cells in time-dependent manner. Histochem Cell Biol 2010; 134:159-169.


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