The main research focus has been centered for several past years around understanding cytoskeleton organization and dynamics, cell adhesion and cell signaling. In particular I am interested in plectin-dependent regulation of the actin and intermediate filament cytoskeleton, adhesion mediated signalling and cell motility using molecular cell biology in various cell types derived from transgenic mice models. Currently I am developing mouse models for studying disease-related, cell biological and molecular aspects of cytoskeletal and other proteins in digestive organs. I am applying my research to the understanding of liver fibrosis, inflammatory bowel diseases and cancerogenesis.
Brauer R., Tureckova J., Kanchev I., Khoylou M., Skarda J., Prochazka J., Spoutil F., Beck I.M., Zbodakova O., Kasparek P., Korinek V., Chalupsky K., Karhu T., Herzig K.H., Hajduch M., Gregor M.*, Sedlacek R.*: MMP-19 deficiency causes aggravation of colitis due to defects in innate immune cell function. Mucosal Immunol., 9:974-85, 2016.
Song J.-G., Kostan J., Drepper F., Knapp B., de Almeida Ribeiro Jr E., Konarev P.V., Grishkovskaya I., Wiche G., Gregor M., Svergun D.I., Warscheid B., Djinović-Carugo K.: Structural insights into Ca2+/calmodulin regulation of plectin 1a - integrin β4 interaction in hemidesmosomes. Structure, 23:558-70, 2015.
Gregor M.*, Osmanagic-Myers S.*, Burgstaller G., Wolfram M., Fischer I., Walko G., Resch G.P., Jörgl A., Herrmann H., Wiche G.: Mechanosensing through focal adhesion-anchored intermediate filaments. FASEB J., 28:715-29, 2014.
Burgstaller G.*, Gregor M.*, Winter L., Wiche G.: Keeping the vimentin network under control: cell–matrix adhesion-associated plectin 1f affects cell shape and polarity of fibroblasts. Mol. Biol. Cell, 21:3362–3375, 2010.
Osmanagic-Myers S.*, Gregor M.*, Walko G.*, Burgstaller G., Reipert S., Wiche G.: Plectin-controlled keratin cytoarchitecture affects MAP kinases involved in cellular stress response and migration. J. Cell Biol. 174: 557-68, 2006.
9-11 September 2019, Trnava, Slovakia