Lautenschläger Franziska

Lautenschläger Franziska Country: Germany
Laboratory webpage
E-mail: f.lautenschlaeger@physik.uni-saarland.de

Participation in Working Groups

  • WG1 - Biophysics of cell and tissue structure

Research Interests

We investigate the role of Intermediate filaments, especially vimentin, on biophysical properties of cells, such as cell migration, stiffness and polarity. We are further interested in the interplay of vimentin with actin and microtubules. Finally, we are investiagting the structure and dynamics of the actin cortex and microtentacles in suspended cells.

Technologies offered to other EuroCellNet participants

High resolution microscopy techniques (Confocal, SEM),

Laser manipulation techniques: Fluorescent Recovery After Photobleaching (FRAP), Laser Ablation

Migration assays of both strongly and weakly adherent cells (e.g. microchambers for immune cell migration)

Adhesive micropatterning

Cell mechanical properties for both adherent and non adherent cells

Technologies sought from other EuroCellNet participants

Cell-biology support

specific drugs targeting IFs

Publications

Danielsson F., K.P. McKenzie, H. Caldeira Araujo, F. Lautenschläger, A.K.B. Gad (2018) “Vimentin Diversity in Health and Disease” Cells, 7(10)

Terriac, E., G. Coceano, Z. Mavajian, T. A. Hageman, A. F. Christ, I. Testa, A. K. Gad, and F. Lautenschlager (2017). "Vimentin Levels and Serine 71 Phosphorylation in the Control of Cell-Matrix Adhesions, Migration Speed, and Shape of Transformed Human Fibroblasts." Cells 6(1).

M. Raab, M. Gentilli, H. de Belly, H.R. Thiam, P. Vargas, A.J. Jimenez, F.Lautenschlaeger, A.M. Lennon Duménil, N. Manel, M. Piel (2016) Lamin A/C and ESCRT III promote the survival of migrating cells by ensuring nuclear envelope integrity and preventing DNA damage. Science 352(6283): 359-362.

C. J. Chan, A. E. Ekpenyong, S. Golfier, W. Li, K. J. Chalut, O. Otto., J. Elgeti, J. Guck, F. Lautenschläger (2015) Myosin II activity softens cells in suspension. Biophysical Journal 108(8): 1856-1869.

Y.-J. Liu, M. Le Berre, F. Lautenschläger, P. Maiuri, A. Callan Jones, T. Takaki, R. Voituriez, M. Piel (2015) Confinement in a non-adhesive environment induces fast amoeboid migration of slow mesenchymal cells. Cell 160(4): p. 659-672.