Tedesco Francesco Saverio
Country: United Kingdom
Laboratory webpage
E-mail: f.s.tedesco@ucl.ac.uk
Participation in Working Groups
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WG1 - Biophysics of cell and tissue structure
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WG2 - Structural analysis of biomolecules involved in mechanobiology
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WG3 - New methodologies to study mechanobiology of cells and tissues
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WG4 - Mechanobiological principles of rare and common diseases
Research Interests
The Tedesco lab at University College London (UK) studies skeletal muscle stem cells and regeneration to develop novel therapies for severe neuromuscular disorders. Their work pioneered the use of human artificial chromosomes and induced pluripotent stem (iPS) cells for muscle gene and cell therapies. Current research projects are investigating the use of small molecules to improve muscle stem cell delivery and the application of iPS cell-derived myogenesis for neuromuscular disease modelling and tissue engineering.
Technologies offered to other EuroCellNet participants
Human artificial chromosome engineering, induced pluripotent stem (iPS) cells for muscle gene and cell therapies. Current research projects are investigating the use of small molecules to improve muscle stem cell delivery and the application of iPS cell-derived myogenesis for neuromuscular disease modelling and tissue engineering.
Technologies sought from other EuroCellNet participants
Bionformatics, stem cell engineering.
Publications
- GERLI MFM, MOYLE LA, BENEDETTI S, FERRARI G, UCUNCU E, RAGAZZI M, CONSTANTINOU C, LOUCA I, SAKAI H, ALA P, DE COPPI P, TAJBAKHSH P, COSSU G, TEDESCO FS. COMBINED NOTCH AND PDGF SIGNALLING ENHANCES MIGRATION AND EXPRESSION OF STEM CELL MARKERS WHILE INDUCING PERIVASCULAR CELL FEATURES IN MUSCLE SATELLITE CELLS. STEM CELL REPORTS, 2019 MAR 5;12(3):461-473. DOI.ORG/10.1016/J.STEMCR.2019.01.007
- STEELE-STALLARD H, PINTON L, SARCAR, S, OZDEMIR T, MAFFIOLETTI SM, ZAMMIT PS AND TEDESCO FS. MODELLING SKELETAL MUSCLE LAMINOPATHIES USING HUMAN INDUCED PLURIPOTENT STEM CELLS CARRYING PATHOGENIC LMNA MUTATIONS. FRONTIERS IN PHYSIOLOGY, 2018 OCT 15 DOI.ORG/10.3389/FPHYS.2018.01332
- MAFFIOLETTI SM, SARCAR S, HENDERSON ABH, MANNHARDT I, PINTON L, MOYLE LA, STEELE-STALLARD H, CAPPELLARI O, WELLS KE, FERRARI G, MITCHELL JS, TYZACK GE, KOTIADIS VN, KHEDR M, RAGAZZI M, WANG W, DUCHEN MR, PATANI R, ZAMMIT P, WELLS D, ESCHENHAGEN T AND TEDESCO FS. THREE-DIMENSIONAL HUMAN IPSC-DERIVED ARTIFICIAL SKELETAL MUSCLES MODEL MUSCULAR DYSTROPHIES AND ENABLE MULTILINEAGE TISSUE ENGINEERING. CELL REPORTS, 2018 APR 17;23(3):899-908. DOI: 10.1016/J.CELREP.2018.03.091.
- BENEDETTI S, UNO N, HOSHIYA H, RAGAZZI M, FERRARI G, KAZUKI Y, MOYLE LA, TONLORENZI R, LOMBARDO A, CHAOUCH A, MOULY V, MOORE M, POPPLEWELL L, KAZUKI K, KATOH M, NALDINI L, DICKSON G, MESSINA G, OSHIMURA M, COSSU G AND TEDESCO FS. REVERSIBLE IMMORTALISATION ENABLES GENETIC CORRECTION OF HUMAN MUSCLE PROGENITORS AND ENGINEERING OF NEXT-GENERATION HUMAN ARTIFICIAL CHROMOSOMES FOR DUCHENNE MUSCULAR DYSTROPHY. EMBO MOLECULAR MEDICINE, 2017 DEC 14. DOI: 10.15252/EMMM.201607284.
- MAFFIOLETTI SM, GERLI MFM, RAGAZZI M, DASTIDAR S, BENEDETTI S, LOPERFIDO M, VANDENDRIESSCHE T, CHUAH M AND TEDESCO FS. EFFICIENT DERIVATION AND INDUCIBLE DIFFERENTIATION OF EXPANDABLE SKELETAL MYOGENIC CELLS FROM HUMAN ES AND PATIENT-SPECIFIC IPS CELLS. NATURE PROTOCOLS, 2015 JUN 4; 10, 941–958 (COVER ARTICLE)
- TEDESCO FS, GERLI M, PERANI L, BENEDETTI S, UNGARO F, CASSANO M, ANTONINI S, TAGLIAFICO E, ARTUSI V, TONLORENZI R, RAGAZZI M, CALDERAZZI G, HOSHIYA H, CAPPELLARI O, MORA M, SAMPAOLESI M, TORRENTE Y, BROCCOLI V AND COSSU G. TRANSPLANTATION OF GENETICALLY CORRECTED HUMAN IPSC-DERIVED PROGENITORS IN MICE WITH LIMB-GIRDLE MUSCULAR DYSTROPHY. SCIENCE TRANSLATIONAL MEDICINE, 2012 JUN 27;4(140):140RA89
- TEDESCO FS, HOSHIYA H, D’ANTONA G, GERLI M, MESSINA G, ANTONINI S, TONLORENZI R, BENEDETTI S, BERGHELLA L, TORRENTE Y, KAZUKI Y, BOTTINELLI R, OSHIMURA M AND COSSU G. STEM CELL-MEDIATED TRANSFER OF A HUMAN ARTIFICIAL CHROMOSOME AMELIORATES MUSCULAR DYSTROPHY. SCIENCE TRANSLATIONAL MEDICINE, 2011 AUG 17;3(96):96RA78 (COVER ARTICLE)